Be aware that the formation of these “uremic toxins” can occur in moderate stage kidney disease. Picture the cells of the intestine like a picket fence, with each of the posts rooted in the ground and attached to one another. The toxins in the intestine can not only cause many of the posts to separate from one another, but also may even cause some of them to uproot from the ground. This is likely an oversimplification, but you get the idea.
The functions of the small intestine are absorption and protection. With the separation of these fence posts (intestinal cells) from one another,a significant aspect of the protective barrier of the intestine is lost. The uremic toxins are able to “escape” into the blood stream and trigger an inflammatory response. For patients with kidney disease, this happens on a sustained basis causing a continued inflammatory response. Add into the mix other things that can affect intestinal health: the overuse of antibiotics, the nutrient poor pro-inflammatory Western diet, psychological and physical stress, Candida overgrowth of the intestine… All are promoters of a “leaky gut” and systemic inflammation. This is why I believe that using probiotics like Renadyl™ will give hope to people with kidney problems and why improving intestinal health is going to be key to lowering systemic inflammation and improving our total body health.
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